Kevin Bohlin opened the first café on Polk Street in 2013, and Saint Frank now has cafés in Russian Hill, the Sunset, and Mira on Folsom Street, plus one in Menlo Park. In 2019 it partnered with the Long Miles Coffee Project to establish a washing station on Ninga Hill in Burundi, and in September 2026 the company reported that more than 17,000 children took part in the Long Miles coffee camp in Burundi.
Bolivia Asunción Java comes from Celso Mayta, and Guatemala's Don Guayo comes from Eduardo Gomez on Volcan de Agua. Barista Jason Yeo placed second at the 2026 US Barista Championship, after two third-place finishes.